AQbD software solution
for automated HPLC
method development
In accordance with ICH guidelines
Method development selections
Column selection
Condition scouting
Method optimization
Retention modelling
DoE and Robustness
Data analysis
Analytic method development
Development of HPLC methods has evolved to concreete, yet complicated process suggesting to employ analytical quality by design (AQbD) and ICH (Q2, Q14) guidelines. These approaches are a systematic and scientific way to develop methods that can deliver reliable and consistent results. The procedure involves identifying critical method parameters (CMPs) that can affect the quality of the analytical method and optimizing them to achieve the desired analytical performance.
Column
selections ATP
Development
workflow
Initial assessment
Screening
Optimization
Method improvement
DoE and MODR
Continous
screening
Method
improvements
ChromSword can help in AQbD process by:
Aiding in creating development plan
Automatically selecting the seperation by controlling the instrument and automatically performing injections
Facilitating the identification of CMPs
Providing the information about optimal selectivity and efficiency during screening stage
Creating the design space models that help identifying proven acceptable ranges (PARs) and method operational design regions (MODRs)
History
More than 30 years of experience in liquid chromatography. Our team is made of highly skilled separation scientists, analytical chemists, mathematicians and IT specialists who transfer their knowledge into the software - developed by analytical chemists for analytical chemists.