AQbD software solution
for automated HPLC
method development

In accordance with ICH guidelines

Method development selections

Column selection

Condition scouting

Method optimization

Retention modelling

DoE and Robustness

Data analysis

Analytic method development

Development of HPLC methods has evolved to concreete, yet complicated process suggesting to employ analytical quality by design (AQbD) and ICH (Q2, Q14) guidelines. These approaches are a systematic and scientific way to develop methods that can deliver reliable and consistent results. The procedure involves identifying critical method parameters (CMPs) that can affect the quality of the analytical method and optimizing them to achieve the desired analytical performance.

Column
selections ATP

Development
workflow

Initial assessment

Screening

Optimization

Method improvement

DoE and MODR

Continous
screening

Method
improvements

ChromSword can help in AQbD process by:

Aiding in creating development plan

Automatically selecting the seperation by controlling the instrument and automatically performing injections

Facilitating the identification of CMPs

Providing the information about optimal selectivity and efficiency during screening stage

Creating the design space models that help identifying proven acceptable ranges (PARs) and method operational design regions (MODRs)

History

More than 30 years of experience in liquid chromatography. Our team is made of highly skilled separation scientists, analytical chemists, mathematicians and IT specialists who transfer their knowledge into the software - developed by analytical chemists for analytical chemists.